Answering buyers’ questions about managing colic and constipation, this guide highlights practical formulas and probiotic options designed to support digestion in infants. The featured products are suitable for babies dealing with tummy woes, cow’s milk protein sensitivity, or digestive discomfort. This overview helps parents choose options that align with their baby’s needs, from hypoallergenic formulas to probiotic drops for daily use. The summary table below compares the five selected products at a glance.
| Product | |||
|---|---|---|---|
| Enfamil Nutramigen Hypoallergenic Baby Formula with Iron (27.8 Oz, 4 Count) | Baby Formula | Colic due to cow’s milk allergy | Clinically-proven relief, includes LGG |
| Enfamil Nutramigen Hypoallergenic Baby Formula with Iron (19.8 Oz Can) | Baby Formula | Protein sensitivity and colic relief | Amino acid-based, fast relief potential |
| Similac Alimentum Hypoallergenic Infant Formula | Baby Formula | Colic due to protein sensitivity | 2’-FL HMO immune support, hypoallergenic |
| Mommy’s Bliss Baby Probiotic Drops Everyday | Probiotic Drops | Digestive comfort, constipation relief | Daily probiotic for babies from birth |
| Legendairy Milk Baby Probiotic Drops Organic | Probiotic Drops | Constipation and gas in newborns | Four probiotic strains, 2 Billion CFUs per serving |
Enfamil Nutramigen Hypoallergenic Formula with Iron

Best for babies with cow’s milk protein allergy. This amino acid-based formula aims to reduce colic caused by protein sensitivity and supports digestive comfort. The product notes indicate fast relief potential with many infants showing improvement within 48 hours. Best for parents seeking a dairy-protein-free option that still provides essential nutrients and immune-supportive ingredients.
Who it’s best for: Infants diagnosed or suspected of cow’s milk protein allergy. Why selected: It targets the root cause of formula-related colic for many babies and includes LGG for gut health. Caution: For some infants, gradual transition is needed to avoid temporary feeding resistance or constipation if not introduced carefully.
Enfamil Nutramigen Hypoallergenic Formula with Iron (19.8 Oz Can)

Best for managing colic due to cow’s milk protein sensitivity. This ready-to-use option is designed for quick feeding adjustments and supports digestive comfort with LGG as part of its probiotic profile. Best for families who want a hypoallergenic, iron-fortified formula. Caution: The product is lactose-free, which can affect tolerance in some infants who do better with small lactose amounts in other formulas.
Similac Alimentum Hypoallergenic Formula

Best for infants with protein sensitivity and persistent colic symptoms. Alimentum is a hypoallergenic option with 2′-FL HMO for immune support. It’s chosen for its strong hypoallergenic claim and rapid potential relief. Caution: Some babies may require a transition period when moving between formulas.
Gelmix Infant Thickener for Breast Milk & Formula

Best for babies who require thickened feeds to reduce spit-ups and improve swallowing. Thickening can assist with reflux and gentle digestion, especially when combined with appropriate formulas. Caution: Thickener use should follow pediatric guidance to avoid over-thickening or choking risks.
Legendairy Milk Baby Probiotic Drops Organic

Best for a multi-strain probiotic approach to support digestion, immunity, and occasional constipation. This product uses four probiotic strains with 2 Billion CFUs per serving, and is marketed as organic. Caution: Some infants may respond better to specific strains; individual variation exists in probiotic effectiveness.
LOVEBUG Probiotic Drops (USDA Organic)

Best for infants seeking a sugar-free, organic probiotic option with clinically studied strains. It targets colic, gas, constipation, and diarrhea while maintaining a clean ingredient profile. Caution: Product availability and exact strain composition can vary by batch; check labeling before use.
Buying Guide
What should I look for in a formula to help colic?
Consider hypoallergenic formulas if cow’s milk protein sensitivity is suspected. Look for amino acid-based or extensively hydrolyzed proteins. Probiotics may support digestion, but consult a pediatrician before introducing a new probiotic during infancy.
When are probiotics appropriate for infants?
Probiotics can be considered for digestive upset, gas, and constipation. Start with a pediatrician’s recommendation and follow labeled dosing. Non-dairy options are available for babies with dairy sensitivity.
Are thickening agents safe for babies?
Thickeners can reduce reflux and spit-ups, but should be used under medical guidance. Always monitor texture and choking risk, and adjust intake as advised by a clinician.
How do I choose between formula and probiotic drops?
For colic due to protein sensitivity, a hypoallergenic formula may be preferred. For digestive discomfort without protein issues, probiotic drops can complement feeding. Some families use a combination under pediatric care.
What practical transition steps help with new formulas?
Introduce one new product at a time, over several days. Watch for signs of intolerance, such as increased fussiness, rashes, or changes in stool. Maintain hydration and consult a clinician if symptoms persist.
FAQ
- Can probiotics cure colic? Probiotics may help reduce certain digestive discomforts and support stool regularity, but they are not a cure for colic. Individual responses vary.
- Is hypoallergenic formula always necessary for colic? Not always; colic can have multiple causes. Hypoallergenic formulas are often targeted when there is suspected cow’s milk protein allergy.
- How quickly can formula relief appear? Some infants show improvement within 24–48 hours; others may take longer depending on underlying causes.
- Are organic probiotics better for infants? Organic certifications describe ingredient handling, but effectiveness depends on strains and CFU counts. Choose well-studied, pediatrician-recommended options.
- Should I mix formula with probiotics? Some plans allow mixing recommended probiotic drops with formula, but follow the product guidelines and pediatrician’s instructions.