Choosing a formula for a colicky baby can be challenging. The following options are widely used for sensitive tummies, gas, and fussiness, with ingredients designed to ease digestion and support growth. This guide highlights five formulas with hypoallergenic blends, hydrolyzed proteins, or prebiotic components that may help reduce colic symptoms. Always consult a pediatrician before changing your baby’s formula.
| Product | Brand | Key Benefit |
|---|---|---|
| Good Start Dr. Brown’s Soothe Pro | Good Start | Hydrolyzed proteins for easier digestion |
| Enfamil Nutramigen Hypoallergenic | Enfamil | Amino acid-based, lactose-free relief for cow’s milk allergy |
| Enfamil Nutramigen 27.8 Oz Can | Enfamil | Hypoallergenic, supports digestion with LGG probiotic |
| Similac 360 Total Care Powder | Similac | 5 HMO prebiotics, immune and digestive support |
| Similac 360 Total Care Ready-To-Feed | Similac | Prebiotic blend, convenient ready-to-feed option |
Good Start Dr. Brown’s Soothe Pro Formula

Good Start Soothe Pro is formulated to support babies with sensitive tummies, gas, fussiness, and spit-up. It uses a high-quality 100% whey protein base to reduce curdling risks and uses an advanced two-step hydrolysis process that makes proteins smaller and easier to digest. The formula aims to address common feeding challenges while delivering complete infant nutrition.
Enfamil Nutramigen Hypoallergenic Formula

Nutramigen Hypoallergenic with iron is designed for babies who struggle with cow’s milk allergy. It is amino-acid-based and lactose-free, providing fast relief for colic symptoms associated with allergies. The formula includes LGG, a probiotic linked to improved digestive health and potential immune support. Clinically proven relief can begin after the first few feedings for many infants.
Enfamil Nutramigen Hypoallergenic (LGG) 27.8 Oz

This larger can of Nutramigen continues the hypoallergenic, lactose-free approach with LGG probiotic support. It is designed to help infants with cow’s milk protein allergies who experience colic symptoms, aiding digestion and comfort from early on. The amino acid-based formula can provide relief for persistent fussiness and support long-term digestion and development.
Similac 360 Total Care Powder

Similac 360 Total Care offers a blend of five HMO prebiotics designed to resemble the prebiotic profile of breast milk. The formula aims to support immune health, brain development, and digestive well-being. It suits infants who require a non-GMO option with added DHA for development and a robust digestive support system to help manage colic symptoms.
Similac 360 Total Care Ready-To-Feed

The ready-to-feed option provides convenient feeding with the same 360 Total Care benefits: five HMO prebiotics, immune support, and DHA for development. This format helps caregivers who prefer a quick, consistent formula without mixing, maintaining steady nutrition and digestibility for babies with sensitivity or colic tendencies.
Buying Guide
Key considerations when selecting a formula for colic-prone babies:
- Protein type: Hydrolyzed or amino acid-based formulas are often chosen for sensitive tummies. These formulas reduce allergen exposure and may ease digestion for infants with cow’s milk allergy.
- Allergen handling: Lactose-free or hypoallergenic options can help infants who show intolerance signs or allergy-related discomfort. LGG or other probiotics may support digestive health.
- Prebiotics and immune support: Formulas containing HMOs or other prebiotics can resemble breast milk composition more closely, potentially aiding immune development and digestion.
- Convenience vs. routine: Ready-to-feed formulas offer convenience, while powders provide cost efficiency and flexibility for daily routines and dosage adjustments.
- Consultation: Always discuss formula changes with a pediatrician, particularly for persistent colic, severe fussiness, or suspected allergies. Individual baby responses vary widely.
- Packaging and storage: Check shelf life, storage requirements, and whether a particular formula suits your household schedule, travel needs, and feeding pace.