Hemorrhoid symptoms like pain, itching, and burning can disrupt daily activities. A high-strength numbing cream can provide targeted relief fast, helping you stay comfortable while you heal. This guide highlights five effective options, comparing ingredients, easing speed, and user considerations to help you choose the best fit for sensitive skin and external use. All products feature lidocaine in varying OTC strengths and are designed for external anorectal use.
Summary table of selected products
| Product | Brand | Active Ingredient / Strength | Size | Notes |
|---|---|---|---|---|
| WELMATE Hemorrhoids Lidocaine Cream | WELMATE | 5% Lidocaine | 2 oz (60 g) | Fast-acting external relief; child-resistant packaging |
| WELMATE Hemorrhoids Lidocaine Cream | WELMATE | 5% Lidocaine | 1 oz (30 g) | Compact travel-size option |
| WELMATE Hemorrhoids Lidocaine Cream | WELMATE | 5% Lidocaine | 6 oz jar | Larger volume for ongoing use |
| AneCream Lidocaine Numbing Cream | AneCream | 5% Lidocaine | 0.5 oz (15 g) | Medical-grade formulation |
| Rectalief Lidocaine Hemorrhoid Cream | Reliable-1 Laboratories | 5% Lidocaine | 2-Pack | Non-greasy, fast-acting |
WELMATE 5% Lidocaine Cream — 2 oz

WELMATE’s 5% Lidocaine Cream is formulated for external use on sensitive anorectal skin. The high concentration provides rapid numbing to alleviate burning, itching, and discomfort associated with hemorrhoids and other anorectal irritations. The cream is designed for external application and is gentle on most skin types, with child-resistant packaging to enhance safety. It balances fast relief with a non-oily feel to minimize staining of undergarments or sheets.
Key considerations: the 5% lidocaine strength matches commonly recommended OTC levels for quick relief. As with all lidocaine products, follow the label directions for amount and frequency to reduce the risk of irritation or systemic absorption, especially for those with sensitive or compromised skin. External-only use is emphasized, and the product is designed for delicate areas.
WELMATE 5% Lidocaine Cream — 1 oz

This compact option provides the same 5% lidocaine formulation in a travel-friendly 1 oz tube. Like other WELMATE variants, it is designed for external anorectal use and aims to deliver fast relief from itching, burning, and pain without heavy greasiness. The packaging remains child-resistant for added safety in shared spaces.
Considerations for use: smaller packaging is convenient for periodic use and quick relief on the go. If you anticipate frequent needs, pairing the 1 oz with the 2 oz or 6 oz jar can ensure ready access at home and travel corridors. Skin sensitivity or history of lidocaine reaction should be screened prior to regular use.
WELMATE 5% Lidocaine Cream — 6 oz Jar

The 6 oz jar is designed for ongoing relief and higher-volume needs. The 5% lidocaine formulation delivers quick numbing to the anorectal area, with a focus on external use and skin safety. The packaging is designed to be user-friendly with a secure seal to maintain product integrity between applications.
Usage guidance: larger jars are cost-efficient for regular users. Ensure the area is clean and dry before application, and avoid applying to broken skin or mucous membranes unless explicitly directed. If itching or burning persists beyond the recommended duration, consult a healthcare professional.
AneCream 5% Lidocaine Numbing Cream

AneCream offers a 5% lidocaine formulation designed for anorectal use and external surfaces. The medical-grade composition targets pain, itching, and burning associated with hemorrhoids, with a quick onset of numbness typically within minutes. This product emphasizes fast-acting relief and includes considerations for daily comfort with external irritations.
Important notes: as with any topical anesthetic, use the smallest amount necessary to achieve relief and avoid contact with eyes or mucous membranes. If you have a history of lidocaine sensitivity, or if you’re pregnant or nursing, consult a healthcare professional before use. Patch testing on a small area is advisable for first-time users to assess tolerance.
Rectalief 5% Lidocaine — 2-Pack

Rectalief’s 5% lidocaine cream is marketed as a max non-prescription strength solution for hemorrhoids. The two-pack design supports dual-use convenience, especially for users who prefer to apply both morning and night or keep one at home and one portable. The formula emphasizes a fast-acting, non-greasy application that dries quickly for discreet use and minimal staining.
Key considerations: fast onset is a hallmark of this product, with emphasis on minimal residue. Because it’s designed for external use, avoid applying to broken skin or near the eyes. People with sensitive skin or a history of topical anesthetic reactions should perform a patch test and monitor for any adverse effects during initial uses.
Buying Guide: Key Purchase Considerations And Comparisons
- Active strength and onset: All products in this guide use 5% lidocaine, a common OTC strength for quick relief. Look for products that advertise a rapid onset (often within minutes) and lasting effect to minimize need for reapplication throughout the day.
- Formulation and texture: Non-greasy, water-based formulations are favored for comfort and clean removal. If you prefer a lighter feel that won’t soil clothing or undergarments, choose a non-greasy option with a quick-drying formula.
- Packaging and safety: Child-resistant packaging adds safety for households with children. Consider the size and packaging when planning storage or travel; smaller tubes are portable, while larger jars may offer better value for regular use.
- Skin compatibility: External anorectal use requires skin-safety considerations. For sensitive skin, review ingredients and consider products marketed for delicate areas. Patch testing a small area can help prevent irritation.
- Usage context: These products are designed for temporary relief of pain, itching, and burning associated with hemorrhoids and anorectal irritation. They should complement, not replace, other hemorrhoid care strategies such as dietary changes, hydration, topical protectants, and medical guidance when needed.
- Brand and product consistency: Different brands provide similar 5% lidocaine strength but may vary in texture, residue, and fragrance. If you have fragrance sensitivities or prefer unscented formulas, confirm labeling to avoid potential irritants.
- Safety and exclusions: These products are for external use only unless specifically indicated otherwise. Do not apply to broken skin or mucous membranes, and avoid contact with eyes. If irritation occurs, discontinue use and seek medical advice.
In selecting a numbing cream for hemorrhoids, consider how quickly relief is needed, how the product feels on your skin, and how often you anticipate applying it. For ongoing symptoms, a larger jar paired with a travel-sized option can provide consistent relief without frequent re-purchases. Always follow label instructions and seek medical guidance if symptoms persist beyond a few days or worsen.